Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex

Antibodies that neutralize infectivity of malaria sporozoites target the central repeat region of the circumsporozoite (CS) protein, which in Plasmodium falciparum is comprised primarily of 30–40 tandem NANP tetramer repeats. We evaluated immunogenicity of an alum-adsorbed (NANP)(6) peptide conjugat...

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Hlavní autoři: Przysiecki, Craig, Lucas, Bob, Mitchell, Robert, Carapau, Daniel, Wen, Zhiyun, Xu, Hui, Wang, Xin-Min, Nahas, Debbie, Wu, Chengwei, Hepler, Robert, Ottinger, Elizabeth, ter Meulen, Jan, Kaslow, David, Shiver, John, Nardin, Elizabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2012
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510440/
https://ncbi.nlm.nih.gov/pubmed/23226683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2012.00146
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