Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex

Antibodies that neutralize infectivity of malaria sporozoites target the central repeat region of the circumsporozoite (CS) protein, which in Plasmodium falciparum is comprised primarily of 30–40 tandem NANP tetramer repeats. We evaluated immunogenicity of an alum-adsorbed (NANP)(6) peptide conjugat...

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Detalhes bibliográficos
Main Authors: Przysiecki, Craig, Lucas, Bob, Mitchell, Robert, Carapau, Daniel, Wen, Zhiyun, Xu, Hui, Wang, Xin-Min, Nahas, Debbie, Wu, Chengwei, Hepler, Robert, Ottinger, Elizabeth, ter Meulen, Jan, Kaslow, David, Shiver, John, Nardin, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510440/
https://ncbi.nlm.nih.gov/pubmed/23226683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2012.00146
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