Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex

Antibodies that neutralize infectivity of malaria sporozoites target the central repeat region of the circumsporozoite (CS) protein, which in Plasmodium falciparum is comprised primarily of 30–40 tandem NANP tetramer repeats. We evaluated immunogenicity of an alum-adsorbed (NANP)(6) peptide conjugat...

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Autores principales: Przysiecki, Craig, Lucas, Bob, Mitchell, Robert, Carapau, Daniel, Wen, Zhiyun, Xu, Hui, Wang, Xin-Min, Nahas, Debbie, Wu, Chengwei, Hepler, Robert, Ottinger, Elizabeth, ter Meulen, Jan, Kaslow, David, Shiver, John, Nardin, Elizabeth
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2012
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510440/
https://ncbi.nlm.nih.gov/pubmed/23226683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2012.00146
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