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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
ALS is a devastating neurodegenerative disease primarily affecting motor neurons. Mutations in TDP-43 cause some forms of the disease, and cytoplasmic TDP-43 aggregates accumulate in degenerating neurons of most ALS patients. Thus, strategies aimed at targeting the toxicity of cytoplasmic TDP-43 agg...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510335/ https://ncbi.nlm.nih.gov/pubmed/23104007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2434 |
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