Relevance of the ACTN4 gene in African Americans with non-diabetic ESRD

BACKGROUND: African Americans (AAs) are predisposed to non-diabetic (non-DM) end-stage renal disease (ESRD) and studies have shown a genetic component to this risk. Rare mutations in ACTN4 (α-actinin-4) an actin binding protein expressed in podocytes cause familial focal segmental glomerulosclerosis...

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Main Authors: Bostrom, Meredith A., Perlegas, Peter, Lu, Lingyi, Hicks, Pamela J., Hawkins, Greg, Ng, Maggie C.Y., Langefeld, Carl D., Freedman, Barry I., Bowden, Donald W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510331/
https://ncbi.nlm.nih.gov/pubmed/22965004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000342205
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