Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis

Initial studies of 88 transmission pairs in the Zambia Emory HIV Research Project cohort demonstrated that the number of transmitted HLA-B associated polymorphisms in Gag, but not Nef, was negatively correlated to set point viral load (VL) in the newly infected partners. These results suggested that...

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Main Authors: Prince, Jessica L., Claiborne, Daniel T., Carlson, Jonathan M., Schaefer, Malinda, Yu, Tianwei, Lahki, Shabir, Prentice, Heather A., Yue, Ling, Vishwanathan, Sundaram A., Kilembe, William, Goepfert, Paul, Price, Matthew A., Gilmour, Jill, Mulenga, Joseph, Farmer, Paul, Derdeyn, Cynthia A., Tang, Jiaming, Heckerman, David, Kaslow, Richard A., Allen, Susan A., Hunter, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510241/
https://ncbi.nlm.nih.gov/pubmed/23209412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003041
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