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Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei Strain 427 by a Whole Cell Viability Based HTS Campaign

Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes and limited efficacy across species and disease...

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Bibliografiske detaljer
Main Authors: Sykes, Melissa L., Baell, Jonathan B., Kaiser, Marcel, Chatelain, Eric, Moawad, Sarah R., Ganame, Danny, Ioset, Jean-Robert, Avery, Vicky M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510080/
https://ncbi.nlm.nih.gov/pubmed/23209849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001896
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