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NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate

Embryonic Stem (ES) cells are able to give rise to the three germ layers of the embryo but are prevented from contributing to the trophoblast. The molecular nature of this barrier between embryonic and trophectodermal cell fates is not clear, but is known to involve DNA methylation. Here we demonstr...

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Detalhes bibliográficos
Main Authors: Latos, Paulina A., Helliwell, Christine, Mosaku, Olukunbi, Dudzinska, Dominika A., Stubbs, Bryony, Berdasco, Maria, Esteller, Manel, Hendrich, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509455/
https://ncbi.nlm.nih.gov/pubmed/23213424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.2012513
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