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Screening Reactive Metabolites Bioactivated by Multiple Enzyme Pathways Using a Multiplexed Microfluidic System

A multiplexed, microfluidic platform to detect reactive metabolites is described, and its performance is illustrated for compounds metabolized by oxidative and bioconjugation enzymes in multi-enzyme pathways to mimic natural human drug metabolism. The device features four 8-electrode screen printed...

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Detalhes bibliográficos
Main Authors: Wasalathanthri, Dhanuka P., Faria, Ronaldo C., Malla, Spundana, Joshi, Amit A., Schenkman, John B., Rusling, James F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509269/
https://ncbi.nlm.nih.gov/pubmed/23095952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2an35993f
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