Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays

The principal central nervous system (CNS) water channel, aquaporin-4 (AQP4), is confined to astrocytic and ependymal membranes and is the target of a pathogenic autoantibody, neuromyelitis optica (NMO)-IgG. This disease-specific autoantibody unifies a spectrum of relapsing CNS autoimmune inflammato...

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Main Authors: Iorio, Raffaele, Fryer, James P., Hinson, Shannon R., Fallier-Becker, Petra, Wolburg, Hartwig, Pittock, Sean J., Lennon, Vanda A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509259/
https://ncbi.nlm.nih.gov/pubmed/22906356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.07.008
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