Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

Neuromyelitis optica (NMO)-immunoglobulin G (IgG) is a clinically validated serum biomarker that distinguishes relapsing central nervous system (CNS) inflammatory demyelinating disorders related to NMO from multiple sclerosis. This autoantibody targets astrocytic aquaporin-4 (AQP4) water channels. C...

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Bibliographic Details
Main Authors: Hinson, Shannon R., Roemer, Shanu F., Lucchinetti, Claudia F., Fryer, James P., Kryzer, Thomas J., Chamberlain, Jayne L., Howe, Charles L., Pittock, Sean J., Lennon, Vanda A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Brief Definitive Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571922/
https://ncbi.nlm.nih.gov/pubmed/18838545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081241
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