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Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action

The pathways leading specifically to the toxic Aβ42 peptide production, a key event in Alzheimer's disease (AD), are unknown. While searching for pathways that mediate pathological increases of Aβ42, we identified Aftin-4, a new compound that selectively and potently increases Aβ42 compared to...

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Bibliografiske detaljer
Main Authors: Bettayeb, Karima, Oumata, Nassima, Zhang, Yuanyuan, Luo, Wenjie, Bustos, Victor, Galons, Hervé, Greengard, Paul, Meijer, Laurent, Flajolet, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509055/
https://ncbi.nlm.nih.gov/pubmed/22972917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-212985
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