A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates

In nonhuman primates, we previously demonstrated that a maternal high-fat diet (MHFD) induces fetal nonalcoholic fatty liver disease (NAFLD) and alters the fetal metabolome. These changes are accompanied by altered acetylation of histone H3 (H3K14ac). However, the mechanism behind this alteration in...

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Bibliografiske detaljer
Main Authors: Suter, Melissa A., Chen, Aishe, Burdine, Marie S., Choudhury, Mahua, Harris, R. Alan, Lane, Robert H., Friedman, Jacob E., Grove, Kevin L., Tackett, Alan J., Aagaard, Kjersti M.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2012
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509051/
https://ncbi.nlm.nih.gov/pubmed/22982377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-212878
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