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Sphingosine-1-Phosphate Rapidly Increases Cortisol Biosynthesis and the Expression of Genes Involved in Cholesterol Uptake and Transport in H295R Adrenocortical Cells
In the acute phase of adrenocortical steroidogenesis, adrenocorticotrophin (ACTH) activates a cAMP/PKA-signaling pathway that promotes the transport of free cholesterol to the inner mitochondrial membrane. We have previously shown that ACTH rapidly stimulates the metabolism of sphingolipids and the...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508734/ https://ncbi.nlm.nih.gov/pubmed/21864647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2011.08.003 |
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