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Acid Ceramidase (ASAH1) Represses Steroidogenic Factor 1-Dependent Gene Transcription in H295R Human Adrenocortical Cells by Binding to the Receptor

Adrenocorticotropin (ACTH) signaling increases glucocorticoid production by promoting the interaction of transcription factors and coactivator proteins with the promoter of steroidogenic genes. The nuclear receptor steroidogenic factor 1 (SF-1) is essential for steroidogenic gene transcription. Sphi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lucki, Natasha C., Li, Donghui, Bandyopadhyay, Sibali, Wang, Elaine, Merrill, Alfred H., Sewer, Marion B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486137/
https://ncbi.nlm.nih.gov/pubmed/22927646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00378-12
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