Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression

In H295R human adrenocortical cells, ACTH rapidly activates ceramide (Cer) and sphingosine (SPH) turnover with a concomitant increase in SPH-1-phosphate secretion. These bioactive lipids modulate adrenocortical steroidogenesis, primarily by acting as second messengers in the protein kinase A/cAMP-de...

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Bibliografske podrobnosti
Main Authors: Lucki, Natasha C., Bandyopadhyay, Sibali, Wang, Elaine, Merrill, Alfred H., Sewer, Marion B.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2012
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275158/
https://ncbi.nlm.nih.gov/pubmed/22261821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1150
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