Next generation sequencing of CLU, PICALM and CR1: pitfalls and potential solutions

CLU, PICALM and CR1 were identified as genetic risk factors for late onset Alzheimer’s disease (AD) in two large genome wide association studies (GWAS) published in 2009, but the variants that convey this alteration in disease risk, and how the genes relate to AD pathology is yet to be discovered. A...

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Detalhes bibliográficos
Main Authors: Lord, Jenny, Turton, James, Medway, Christopher, Shi, Hui, Brown, Kristelle, Lowe, James, Mann, David, Pickering-Brown, Stuart, Kalsheker, Noor, Passmore, Peter, Morgan, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508540/
https://ncbi.nlm.nih.gov/pubmed/23205178
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