Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

Recent data have shown that TLR4 performs a key role in cerebral ischemia-reperfusion injury which serves as the origin of the immunological inflammatory reactions. However, the therapeutic effects of pharmacological inhibitions of TLR4 and its immediate down-stream pathway remain to be uncovered. I...

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Bibliografski detalji
Glavni autori: Suzuki, Yukiya, Hattori, Kozo, Hamanaka, Junya, Murase, Tetsuji, Egashira, Yusuke, Mishiro, Keisuke, Ishiguro, Mitsunori, Tsuruma, Kazuhiro, Hirose, Yoshinobu, Tanaka, Hiroyuki, Yoshimura, Shinichi, Shimazawa, Masamitsu, Inagaki, Naoki, Nagasawa, Hideko, Iwama, Toru, Hara, Hideaki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508453/
https://ncbi.nlm.nih.gov/pubmed/23193438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00896
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