Phosphodiesterase-III Inhibitor Prevents Hemorrhagic Transformation Induced by Focal Cerebral Ischemia in Mice Treated with tPA

The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation. Mice subjected to 6-h middle cerebral artery occlusion were treated with delayed tPA alone at 6 h, with combined t...

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Detalhes bibliográficos
Main Authors: Ishiguro, Mitsunori, Mishiro, Keisuke, Fujiwara, Yasuyuki, Chen, Huayue, Izuta, Hiroshi, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Yoshimura, Shinichi, Satoh, Masahiko, Iwama, Toru, Hara, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997776/
https://ncbi.nlm.nih.gov/pubmed/21151895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015178
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