Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

In most solid cancers, cells harboring oncogenic mutations represent only a sub-fraction of the entire population. Within this sub-fraction the expression level of mutated proteins can vary significantly due to cellular variability limiting the efficiency of targeted therapy. To address the causes o...

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Bibliographic Details
Main Authors: Meyer, René, D'Alessandro, Lorenza A., Kar, Sandip, Kramer, Bernhard, She, Bin, Kaschek, Daniel, Hahn, Bettina, Wrangborg, David, Karlsson, Johan, Kvarnström, Mats, Jirstrand, Mats, Lehmann, Wolf-Dieter, Timmer, Jens, Höfer, Thomas, Klingmüller, Ursula
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2012
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508424/
https://ncbi.nlm.nih.gov/pubmed/23226133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00451
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