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Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans

BACKGROUND: The human granulocyte colony-stimulating factor (G-CSF) is routinely applied to support recovery of granulopoiesis during the course of cytotoxic chemotherapies. However, optimal use of the drug is largely unknown. We showed in the past that a biomathematical compartment model of human g...

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Detalhes bibliográficos
Main Authors: Scholz, Markus, Schirm, Sibylle, Wetzler, Marcus, Engel, Christoph, Loeffler, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507764/
https://ncbi.nlm.nih.gov/pubmed/22846180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-9-32
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