Increased p66Shc in the Inner Ear of D-Galactose-Induced Aging Mice with Accumulation of Mitochondrial DNA 3873-bp Deletion: p66Shc and mtDNA Damage in the Inner Ear during Aging

Aging has been associated with mitochondrial DNA damage. P66Shc is an age-related adaptor protein that has a substantial impact on mitochondrial metabolism through regulation of the cellular response to oxidative stress. Our study aimed to establish a D-galactose (D-gal)-induced inner ear aging mous...

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Detalhes bibliográficos
Main Authors: Wu, Lisa, Sun, Yu, Hu, Yu-Juan, Yang, Yang, Yao, Ling-Li, Zhou, Xing-Xing, Wang, Hao, Zhang, Rui, Huang, Xiang, Kong, Wei-Jia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507679/
https://ncbi.nlm.nih.gov/pubmed/23209752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050483
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