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Identifying mutation regions for closely related individuals without a known pedigree

BACKGROUND: Linkage analysis is the first step in the search for a disease gene. Linkage studies have facilitated the identification of several hundred human genes that can harbor mutations leading to a disease phenotype. In this paper, we study a very important case, where the sampled individuals a...

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Main Authors: Cui, Wenjuan, Wang, Lusheng
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507658/
https://ncbi.nlm.nih.gov/pubmed/22731852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-146
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