The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling

NF-κB transcription factors play a key role in regulating the growth of neural processes in the developing PNS. Although several secreted proteins have been shown to activate NF-κB to inhibit the growth of developing sympathetic neurons, it is unknown how the endogenous level of NF-κB activity prese...

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Hlavní autoři: McKelvey, Laura, Gutierrez, Humberto, Nocentini, Giuseppe, Crampton, Sean J., Davies, Alun M., Riccardi, Carlo R., O’keeffe, Gerard W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507174/
https://ncbi.nlm.nih.gov/pubmed/23213379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20121024
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