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Interruption of CXCL13-CXCR5 Axis Increases Upper Genital Tract Pathology and Activation of NKT Cells following Chlamydial Genital Infection

BACKGROUND: Regulation of immune responses is critical for controlling inflammation and disruption of this process can lead to tissue damage. We reported that CXCL13 was induced in fallopian tube tissue following C. trachomatis infection. Here, we examined the influence of the CXCL13-CXCR5 axis in c...

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Autori principali: Jiang, Janina, Karimi, Ouafae, Ouburg, Sander, Champion, Cheryl I., Khurana, Archana, Liu, Guangchao, Freed, Amanda, Pleijster, Jolein, Rozengurt, Nora, Land, Jolande A., Surcel, Helja-Marja, Tiitinen, Aila', Paavonen, Jorma, Kronenberg, Mitchell, Morré, Servaas A., Kelly, Kathleen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506621/
https://ncbi.nlm.nih.gov/pubmed/23189125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047487
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