Prediction of Protein-Destabilizing Polymorphisms by Manual Curation with Protein Structure

The relationship between sequence polymorphisms and human disease has been studied mostly in terms of effects of single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions that change protein structure and function. However, less attention has been paid to more drastic sequenc...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Gough, Craig Alan, Homma, Keiichi, Yamaguchi-Kabata, Yumi, Shimada, Makoto K., Chakraborty, Ranajit, Fujii, Yasuyuki, Iwama, Hisakazu, Minoshima, Shinsei, Sakamoto, Shigetaka, Sato, Yoshiharu, Suzuki, Yoshiyuki, Tada-Umezaki, Masahito, Nishikawa, Ken, Imanishi, Tadashi, Gojobori, Takashi
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2012
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506574/
https://ncbi.nlm.nih.gov/pubmed/23189203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050445
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