PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4

Peroxisome proliferator-activated receptor alpha (PPARα) has been implicated in the pathogenesis of cardiac hypertrophy, although its mechanism of action remains largely unknown. To determine the effect of PPARα activation on endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and explore its mole...

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Detalhes bibliográficos
Main Authors: Le, Kang, Li, Ruifang, Xu, Suowen, Wu, Xiaoqian, Huang, Heqing, Bao, Yingxia, Cai, Yi, Lan, Tian, Moss, Joel, Li, Cuixian, Zou, Jian, Shen, Xiaoyan, Liu, Peiqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506254/
https://ncbi.nlm.nih.gov/pubmed/22198280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.11.024
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