(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection

A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC(50) = 2.3 ± 0.8...

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Détails bibliographiques
Auteurs principaux: Moore, Blake P., Chung, Dong Hoon, Matharu, Daljit S., Golden, Jennifer E., Maddox, Clinton, Rasmussen, Lynn, Noah, James W., Sosa, Melinda I., Ananthan, Subramaniam, Tower, Nichole, A., White, E. Lucile, Jia, Fuli, Prisinzano, Thomas E., Aubé, Jeffrey, Jonsson, Colleen B., Severson, William E.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506029/
https://ncbi.nlm.nih.gov/pubmed/23043370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300612z
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