(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection

A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC(50) = 2.3 ± 0.8...

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Detalhes bibliográficos
Main Authors: Moore, Blake P., Chung, Dong Hoon, Matharu, Daljit S., Golden, Jennifer E., Maddox, Clinton, Rasmussen, Lynn, Noah, James W., Sosa, Melinda I., Ananthan, Subramaniam, Tower, Nichole, A., White, E. Lucile, Jia, Fuli, Prisinzano, Thomas E., Aubé, Jeffrey, Jonsson, Colleen B., Severson, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506029/
https://ncbi.nlm.nih.gov/pubmed/23043370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300612z
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