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Crossover Inhibition as an Indicator of Convergent Evolution of Enzyme Mechanisms: A β-Lactamase and a N-Terminal Nucleophile Hydrolase
O-Aryloxycarbonyl hydroxamates and 1,3,4-oxathiazol-2-ones have been identified as covalent inhibitors of β-lactamases and proteasomes, respectively. The products of these inhibition reactions are remarkably similar, involving carbonyl cross-linking of the active sites. We have cross-checked these i...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3505995/ https://ncbi.nlm.nih.gov/pubmed/23098756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.10.019 |
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