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Serendipitous Discovery of α-Hydroxyalkyl Esters as β-Lactamase Substrates

O-(1-Carboxy-1-alkyloxycarbonyl) hydroxamates were found to spontaneously decarboxylate in aqueous neutral buffer to form O-(2-hydroxyalkylcarbonyl) hydroxamates. While the former molecules do not react rapidly with serine β-lactamases, the latter are quite good substrates of representative classes...

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Detalhes bibliográficos
Main Authors: Pelto, Ryan B., Pratt, R. F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999657/
https://ncbi.nlm.nih.gov/pubmed/21087009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101071r
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