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Serendipitous Discovery of α-Hydroxyalkyl Esters as β-Lactamase Substrates
O-(1-Carboxy-1-alkyloxycarbonyl) hydroxamates were found to spontaneously decarboxylate in aqueous neutral buffer to form O-(2-hydroxyalkylcarbonyl) hydroxamates. While the former molecules do not react rapidly with serine β-lactamases, the latter are quite good substrates of representative classes...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2999657/ https://ncbi.nlm.nih.gov/pubmed/21087009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101071r |
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