Notch Signaling is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

BACKGROUND & AIMS: The Notch signaling pathway is activated in leukemia and solid tumors (such as lung cancer), but little is known about its role in liver cancer. METHODS: The intracellular domain of Notch was conditionally expressed in hepatoblasts and their progeny (hepatocytes and cholangioc...

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Main Authors: Villanueva, Augusto, Alsinet, Clara, Yanger, Kilangsungla, Hoshida, Yujin, Zong, Yiwei, Toffanin, Sara, Rodriguez-Carunchio, Leonardo, Solé, Manel, Thung, Swan, Stanger, Ben Z., Llovet, Josep M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505826/
https://ncbi.nlm.nih.gov/pubmed/22974708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.09.002
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