The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H(2)O(2) and Plays an Integral Role in Insulin Signal Transduction

Insulin stimulation of target cells elicits a burst of H(2)O(2) that enhances tyrosine phosphorylation of the insulin receptor and its cellular substrate proteins as well as distal signaling events in the insulin action cascade. The molecular mechanism coupling the insulin receptor with the cellular...

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Detalhes bibliográficos
Main Authors: Mahadev, Kalyankar, Motoshima, Hiroyuki, Wu, Xiangdong, Ruddy, Jean Marie, Arnold, Rebecca S., Cheng, Guangjie, Lambeth, J. David, Goldstein, Barry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC350558/
https://ncbi.nlm.nih.gov/pubmed/14966267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.5.1844-1854.2004
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