ATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90(rsk) Signaling Pathway in Response to Distinct Forms of DNA Damage

We have identified a novel pathway of ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) signaling that results in nuclear factor κB (NF-κB) activation and chemoresistance in response to DNA damage. We show that the anthracycline doxorubicin (DOX) and its congener N-benzyl...

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Detalhes bibliográficos
Main Authors: Panta, Ganesh R., Kaur, Swayamjot, Cavin, Lakita G., Cortés, Maria L., Mercurio, Frank, Lothstein, Leonard, Sweatman, Trevor W., Israel, Mervyn, Arsura, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC350545/
https://ncbi.nlm.nih.gov/pubmed/14966265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.5.1823-1835.2004
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