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Technical and biological variance structure in mRNA-Seq data: life in the real world
BACKGROUND: mRNA expression data from next generation sequencing platforms is obtained in the form of counts per gene or exon. Counts have classically been assumed to follow a Poisson distribution in which the variance is equal to the mean. The Negative Binomial distribution which allows for over-di...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3505161/ https://ncbi.nlm.nih.gov/pubmed/22769017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-304 |
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