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Technical and biological variance structure in mRNA-Seq data: life in the real world

BACKGROUND: mRNA expression data from next generation sequencing platforms is obtained in the form of counts per gene or exon. Counts have classically been assumed to follow a Poisson distribution in which the variance is equal to the mean. The Negative Binomial distribution which allows for over-di...

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Autori principali: Oberg, Ann L, Bot, Brian M, Grill, Diane E, Poland, Gregory A, Therneau, Terry M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505161/
https://ncbi.nlm.nih.gov/pubmed/22769017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-304
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