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Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis
The mammalian ORMDL proteins are orthologues of the yeast Orm proteins (Orm1/2), which are regulators of ceramide biosynthesis. In mammalian cells, ceramide is a proapoptotic signaling sphingolipid, but it is also an obligate precursor to essential higher order sphingolipids. Therefore levels of cer...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504734/ https://ncbi.nlm.nih.gov/pubmed/23066021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.404012 |
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