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Structural Origins of DNA Target Selection and Nucleobase Extrusion by a DNA Cytosine Methyltransferase

Epigenetic methylation of cytosine residues in DNA is an essential element of genome maintenance and function in organisms ranging from bacteria to humans. DNA 5-cytosine methyltransferase enzymes (DCMTases) catalyze cytosine methylation via reaction intermediates in which the DNA is drastically rem...

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Hlavní autoři: Didovyk, Andriy, Verdine, Gregory L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504724/
https://ncbi.nlm.nih.gov/pubmed/23012373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413054
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