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Covalent binding and hemolytic activity of complement proteins.

We report the inactivation of the third component of complement (C3) by hydroxylamine. C3 hemolytic and covalent binding activities decline with identical kinetics, demonstrating a direct correlation between the two activities. We conclude that covalent, surface-bound C3b is hemolytically active. Th...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Law, S K, Lichtenberg, N A, Levine, R P
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1980
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350468/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6938964/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7194
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