An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3′-end formation

Formation of the 3′ end of RNA polymerase II–transcribed snRNAs requires a poorly understood group of proteins called the Integrator complex. Here we used a fluorescence-based read-through reporter that expresses GFP in response to snRNA misprocessing and performed a genome-wide RNAi screen in Droso...

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Main Authors: Chen, Jiandong, Ezzeddine, Nader, Waltenspiel, Bernhard, Albrecht, Todd R., Warren, William D., Marzluff, William F., Wagner, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504667/
https://ncbi.nlm.nih.gov/pubmed/23097424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035725.112
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