Intramolecular interactions stabilizing compact conformations of the intrinsically disordered kinase-inhibitor domain of Sic1: a molecular dynamics investigation

Cyclin-dependent kinase inhibitors (CKIs) are key regulatory proteins of the eukaryotic cell cycle, which modulate cyclin-dependent kinase (Cdk) activity. CKIs perform their inhibitory effect by the formation of ternary complexes with a target kinase and its cognate cyclin. These regulators generall...

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Detalhes bibliográficos
Main Authors: Lambrughi, Matteo, Papaleo, Elena, Testa, Lorenzo, Brocca, Stefania, De Gioia, Luca, Grandori, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504315/
https://ncbi.nlm.nih.gov/pubmed/23189058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00435
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