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Studies toward the Unique Pederin Family Member Psymberin: Structure Activity Relationships, Biochemical Studies and Genetics Identify the Mode of Action of Psymberin

Psymberin is the only member of the pederin natural product family that contains a dihydroisocoumarin side chain. Structural modifications of psymberin uncoupled inhibition of protein translation from cytotoxicity, suggesting that psymberin has more than one bioactivity. A forward genetic screen in...

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Main Authors: Wu, Cheng-Yang, Feng, Yu, Cardenas, Eduardo R., Williams, Noelle, Floreancig, Paul E., De Brabander, Jef K., Roth, Michael G.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504174/
https://ncbi.nlm.nih.gov/pubmed/23088155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3057002
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