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Life-long persistent viral infection alters the naïve T-cell pool, impairing CD8 T-cell immunity in late life()
Persistent CMV infection has been associated with immune senescence. To address the causal impact of life-long persistent viral infection on immune homeostasis and defense, we infected young mice systemically with HSV-1, MCMV or both viruses, and studied their T-cell homeostasis and function. Herpes...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504138/ https://ncbi.nlm.nih.gov/pubmed/23087407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201867 |
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