Gefitinib Analogue V1801 Induces Apoptosis of T790M EGFR-Harboring Lung Cancer Cells by Up-Regulation of the BH-3 Only Protein Noxa

Treatment of non-small cell lung cancer (NSCLC) with drugs targeting the epidermal growth factor receptor (EGFR), e.g., gefitinib and erlotinib, will eventually fail because of the development of secondary mutations such as T790M in EGFR. Strategies to overcome this resistance are therefore an urgen...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhang, Bo, Jiao, Jiao, Liu, Ying, Guo, Liang-Xia, Zhou, Bo, Li, Gang-Qin, Yao, Zhu-Jun, Zhou, Guang-Biao
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2012
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504066/
https://ncbi.nlm.nih.gov/pubmed/23185274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048748
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