Single Nucleotide Polymorphism rs17849071 G/T in the PIK3CA Gene Is Inversely Associated with Follicular Thyroid Cancer and PIK3CA Amplification

The proto-oncogene PIK3CA has been well studied for its activating mutations and genomic amplifications but not single nucleotide polymorphism (SNP) in thyroid cancer. We investigated SNP rs17849071 (minor allele G and major allele T) in PIK3CA in thyroid tumors in 503 subjects by PCR and sequencing...

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Detalhes bibliográficos
Main Authors: Xing, Jeffrey C., Tufano, Ralph P., Murugan, Avaniyapuram Kannan, Liu, Dingxie, Wand, Gary, Ladenson, Paul W., Xing, Mingzhao, Trink, Barry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504026/
https://ncbi.nlm.nih.gov/pubmed/23185308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049192
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