Cerebrospinal Fluid Matrix Metalloproteinases Are Elevated in Cerebral Adrenoleukodystrophy and Correlate with MRI Severity and Neurologic Dysfunction

BACKGROUND: X-linked adrenoleukodystrophy results from mutations in the ABCD1 gene disrupting the metabolism of very-long-chain fatty acids. The most serious form of ALD, cerebral adrenoleukodystrophy (cALD), causes neuroinflammation and demyelination. Neuroimaging in cALD shows inflammatory changes...

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Detalhes bibliográficos
Main Authors: Thibert, Kathryn A., Raymond, Gerald V., Nascene, David R., Miller, Weston P., Tolar, Jakub, Orchard, Paul J., Lund, Troy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503955/
https://ncbi.nlm.nih.gov/pubmed/23185624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050430
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