Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions.

In humans the alpha-globin genes are duplicated and closely linked. Whereas individuals heterozygous for most alpha-chain mutations possess approximately 25% abnormal hemoglobin, heterozygotes for the alpha-chain variant Hb G Philadelphia synthesize either 33% or 50% Hb G. Both variable gene dosage...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Sancar, G B, Tatsis, B, Cedeno, M M, Rieder, R F
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1980
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350393/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6935689/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.11.6874
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