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Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions.

In humans the alpha-globin genes are duplicated and closely linked. Whereas individuals heterozygous for most alpha-chain mutations possess approximately 25% abnormal hemoglobin, heterozygotes for the alpha-chain variant Hb G Philadelphia synthesize either 33% or 50% Hb G. Both variable gene dosage...

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Detalhes bibliográficos
Main Authors: Sancar, G B, Tatsis, B, Cedeno, M M, Rieder, R F
Formato: Artigo
Idioma:Inglês
Publicado em: 1980
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC350393/
https://ncbi.nlm.nih.gov/pubmed/6935689
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