Multiple-Clone Activation of Hypnozoites Is the Leading Cause of Relapse in Plasmodium vivax Infection

BACKGROUND: Plasmodium vivax infection is characterized by a dormant hepatic stage, the hypnozoite that is activated at varying periods of time after clearance of the primary acute blood-stage, resulting in relapse. Differentiation between treatment failure and new infections requires characterizati...

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Bibliographic Details
Main Authors: de Araujo, Flávia Carolina F., de Rezende, Antônio Mauro, Fontes, Cor Jesus F., Carvalho, Luzia Helena, Alves de Brito, Cristiana F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503861/
https://ncbi.nlm.nih.gov/pubmed/23185469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049871
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