Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies

BACKGROUND: Activated mast cells are present within airway smooth muscle (ASM) bundles in eosinophilic asthma. ASM production of the chemokine CXCL10 plays a role in their recruitment. Thus the effects of glucocorticoids (fluticasone, budesonide), long-acting β2-agonists (salmeterol, formoterol) and...

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Autors principals: Seidel, Petra, Alkhouri, Hatem, Lalor, Daniel J, Burgess, Janette K, Armour, Carol L, Hughes, J Margaret
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503570/
https://ncbi.nlm.nih.gov/pubmed/23034049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-90
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