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Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

Most animal studies using passive administration of HIV broadly neutralizing monoclonal antibodies (bnMAbs) have associated protection against high-dose mucosal viral challenge with relatively high serum concentrations of antibody. We recently identified several bnMAbs remarkable for their in vitro...

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Bibliografske podrobnosti
Main Authors: Moldt, Brian, Rakasz, Eva G., Schultz, Niccole, Chan-Hui, Po-Ying, Swiderek, Kristine, Weisgrau, Kimberly L., Piaskowski, Shari M., Bergman, Zachary, Watkins, David I., Poignard, Pascal, Burton, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503218/
https://ncbi.nlm.nih.gov/pubmed/23100539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214785109
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